Staying in a gaming vibe for ... well, whenever the hell I get bored with it, Alice at Wonderland: leads us to this: mapping famous scenes and sets from movies using Unreal Tournament build engine.
Two notes off this -- from a film-making standpoint, there are several software packages that allow one to storyboard your shots. You actually build your set/location in the software, and then you can literally move your camera around, see where you'll wind up smacking into walls, etc. The problem unfortunately is that graphically they're all pretty much crap. They give you, as far as I can tell, very little advantage over pencil storyboards and a good DP. (if someone's used these and loved them, I'd love to hear the story) If some bright young fella licensed the Unreal Engine and smacked it together with the camera gizmos in such software -- essentially took the rough edges of machinima/in game moviemaking and ported it back out to rl movie-making, they may be able to make a nice little splash.
(Now that I'm in theory taking some time off, I want to try to crack the filmmaking in Sims 2. That seems like a good half-step. Although Molyneux's The Movies looks fascinating)
Second, a quick build of rl locations for instructional purposes becomes even more viable. The military's already using commercially available games for training. If a new student at a particularly maze-like campus, like say MIT (which I believe has one building with the third longest series of continuous corridors in the world, right behind the Kremlin and the Pentagon) had that campus available as a 3-D game map, how helpful would that be for incoming freshmen?
... Although the majority of the readers here aren't gamers like I am, but a few of you will know what I mean: if you were to somehow transport me physically to WoW and drop me in Khaz Modan or Ogrimmar, I could run to the bank, pick up my dry cleaning and be bac k at the inn before you could finish grunting "Stop touching meeee!"